Les actualités PRISM

Détecter en continu le taux de glucose dans le sang est vital à l‘organisme pour qu’il anticipe les hypoglycémies et limite les hyperglycémies qui sont toutes les deux néfastes, en particulier au cours du diabète. Deux capteurs existent chez les mammifères : un au niveau du cerveau et l’autre au niveau de l’abdomen. Grâce à une méthodologie d’imagerie innovante, INRAE et l’Université Adélaïde (Australie) ont, pour la première fois, réussi à quantifier l’activité du capteur de glucose au niveau de l’abdomen chez l’animal et l’Homme. Leurs résultats, publiés dans trois articles, montrent la disparition de ce capteur au cours de l’obésité. Leur étude ouvre de nouvelles perspectives thérapeutiques visant à la restauration de ce capteur pour prévenir des conséquences néfastes de l’obésité comme l’installation d’un diabète de type II.

le communique de presse complet

En 2015,

l’UMR NuMeCan s’investie avec la plateforme PRISM pour développer l’IRM in vivo sur le modèle porcin, tout à la fois sur le porc d’élevage et le miniporc. Ces développements portent :

  • sur l’IRM fonctionnelle pour explorer les réponses cérébrales à des stimulations visuelles, acoustiques, ou olfactogustatives,
  • l’IRM anatomique,
  • l’IRM spectroscopique
  • l’IRM de perfusion cérébrale, etc..

Ces travaux ont été implémentés dans le cadre de différentes stratégies thérapeutiques en nutrition et santé, incluant l’utilisation d’ingrédients alimentaires fonctionnels, de la chirurgie bariatrique, de l’électroacupuncture, ou de la transplantation d’organes.

Ces avancées ont été rendues possibles par la synergie entre les expertises scientifiques de NuMeCan et les offres technologiques et méthodologiques combinées de la plateforme PRISM, de l’UE3P, et du CSCGA1. Aujourd’hui, ces entités proposent une offre globale et parfaitement opérationnelle couplant imagerie, chirurgie et gestion expérimentale dédiées au modèle porcin.

Depuis 2017, le bilan est remarquable

Plus de 150 porcs scannés en IRM, une dizaine de projets et 7 articles publiés (dont 2 revues de synthèse) sur les travaux en IRM sur le modèle porcin. Sur la base de ce bilan, PRISM et NuMeCan ont présenté un projet structurant à leurs tutelles, validant que NuMeCan devient une UMR support de PRISM, avec l’implication de 4 personnels INRAE (dont David VAL-LAILLET, directeur NuMeCan INRAE et pilote scientifique CSCGA). NuMeCan accueillera également dans son équipe le nouveau responsable de la composante Bio-SCANs, Pierre-Antoine ELIAT (IR, personnel Biosit, Université de Rennes 1).

Une nouvelle ambition

Cette association a pour objectif de conforter la place de leader à Rennes de INRAE, de l’Université Rennes 1 et de PRISM sous l’égide de FLI et de Biogenouest dans le domaine de l’expérimentation sur le modèle porc faisant appel à l’imagerie et à la chirurgie. L’ambition est d’apporter aux partenaires académiques, cliniques et industriels une offre globale et cohérente pour la recherche en agroalimentaire, nutrition, santé et neurosciences, mais aussi pour la recherche médicale et chirurgicale.

Personnes contact : David VAL-LAILLET, responsable NuMeCan INRAE, david.val-laillet@inrae.fr Pierre-Antoine ELIAT, responsable Bio-SCANs, Université Rennes 1, pierre-antoine.eliat@univ-rennes1.fr François MARIETTE, responsable PRISM, francois.mariette@inrae.fr

1 Centre de Simulation en Chirurgie du Gros Animal

Bondon, A. El Harras, O. Delalande, I. Nicolas, V. Bordeau, B. Felden New family of azab3 pseudopeptides active on multi-resistant bacteria. 5ème journées du GDR MuFoPAM, Paris, 11-12 octobre 2018.

El Harras, I. Nicolas, V. Bordeau, M. Baudy Floc’h, B. Felden, A. Bondon trNOE: un outil pour la détermination des structures 3D de pseudopeptides actifs sur les bactéries multi-résistantes en interaction avec différents modèles membranaires. GERM, Oléron, 26-29 mai 2019.

Bondon, A. El Harras, I. Nicolas, V. Bordeau, M. Baudy Floc’h, B. Felden Nouveaux antibiotiques efficaces contre des bactéries Gram + et les Gram – multi-résistantes n’induisant que très peu de résistance. 6ème journées du GDR MuFoPAM, Besançon, 17-18 octobre 2019.

MARAGE, J. LASBLEIZ, M. LEDERLIN, H. SAINT-JALMES, G. GAMBAROTA. Intravoxel incoherent motion (IVIM) MRI in wrist bone marrow using the multishot readout-segmented (RESOLVE) echo planar imaging sequence. ESMRMB 2019, 3-5 Oct 2019, Rotterdam, NL

MARAGE, J. LASBLEIZ, M. LEDERLIN, G. GAMBAROTA, H. SAINT-JALMES. MRI of wrist bone marrow: isotropic mapping of fat fraction, water and fat T1 and T2* relaxation times. ESMRMB 2019, 3-5 Oct 2019, Rotterdam, NL

SCIORTINO F, GOUBAULT C, JACOBCZYK H, ELIAT P.-A., TROADEC M-B., GAILLARD C., KAHN M. L., CHEVANCE S., GAUFFRE F., Hybridosomes®: Innovative Multifunctional Nanocapsules from the Ouzo Effect. 33rd Conference of The European Colloid and Interface Society, 8-13 septembre 2019, KU Leuven, Belgium.

TOURÉ S., CUTRI E, ROLLAND Y, SAINT-JALMES H. BÉZY-WENDLING J., ELIAT P.-A. Modélisation spécifique patient de la radioembolisation des tumeurs : de l’acquisition des images à l’initialisation des modèles. XXVIIème congrès du GRETSI, 26-29 août 2019, Lille, France. Poster.

LEMAIRE L. « IRM: histologie virtuelle et au delà ». In : Journée d’animation scientifique des axes exploration fonctionnelle et Bio-imagerie de Biogenouest: ‘Imagerie fonctionnelle pré-clinique’. 24/06/2019, Rennes.

TOURÉ S., CUTRI E, ROLLAND Y, SAINT-JALMES H. BÉZY-WENDLING J., ELIAT P.-A. Segmentation of Hepatic arterial Cone-beam CT Angiography: Comparison of vessels enhancement methods. 33rd International Congress and Exhibition CARS, 18-21 juin 2019, Rennes, France. Poster

LEMAIRE L. « Les nanocapsules lipidiques : Vecteurs thérapeutiques et senseur d’oxygènation ». In : Journée scientifique du laboratoire des Intéractions Moléculaires Chimiques et Photochimiques: ‘Matières molles et chimie analytique’. 18 juin 2019.

TOURÉ S., CUTRI E, ROLLAND Y, SAINT-JALMES H. BÉZY-WENDLING J., ELIAT P.-A. Segmentation de l’artère hépatique : comparaison des filtres de rehaussement de vaisseaux. RITS, 20-22 mai 2019, Tours, France. Poster.

TOURÉ S., CUTRI E, ROLLAND Y, SAINT-JALMES H. BÉZY-WENDLING J., ELIAT P.-A. Filtrage adaptatif de Frangi pour la segmentation d’images 3D d’angiographie Cone-Beam CT du système artériel hépatique. RITS, 20-22 mai 2019, Tours, France. Poster.

MARAGE, J. LASBLEIZ, M. LEDERLIN, G. GAMBAROTA, H. SAINT-JALMES. Correlation between Fat Fraction and MR relaxation times in the vertebral bone marrow at 1.5 T. ISMRM 27th Annual Meeting, 11-16 May 2019, Montréal, QC, Canada

MARAGE, J. LASBLEIZ, M. LEDERLIN, G. GAMBAROTA, H. SAINT-JALMES. Regional differences of IVIM-measured perfusion fraction in vertebral bone marrow at 1.5 T. ISMRM 27th Annual Meeting, 11-16 May 2019, Montréal, QC, Canada

CHIAVACCI L., LALLO DA SILVA B., BERBEL MANAIA E., LEPELTIER E., BENOÎT J. – P., LEMAIRE L. « ZnO based Quantum Dots for Magnetic Resonance and Fluorescence Imaging ». In : 4th World Congress on Recent Advances in Nanotechnology. 14-16 avril 2019, Roma.

BEAUMONT J, SAINT-JALMES H, ACOSTA O, KOBER T, TANNER M, FERRÉ JC, SALVADO O, FRIPP J, GAMBAROTA G. High Contrast T1-Weigthed MRI with Fluid and White Matter Suppression Using MP2RAGE.. 2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI), April 8-11, 2019, Venice, Italy

LARGENT A, NUNES JC, SAINT-JALMES H, BAXTER J, GREER PB, DOWLING JA, ACOSTA O, DE CREVOISIER R. Pseudo-Ct Generation for Mri-Only Radiotherapy: Comparative Study between a Generative Adversarial Network, a U-Net Network, a Patch-Based, and an Atlas Based Methods. 2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI), April 8-11, 2019, Venice, Italy

LALLO DA SILVA B., LEMAIRE L., LEPELTIER E., BENOÎT J. – P., CHIAVACCI L. « Association of ZnO and GCIS/ZnS Quantum dots with optimized photoluminescence properties ». In : Gen2bio. 14/03/2019, Angers.

NEL J., FRANCONI F., DESMET C. M., JOUDIOU N., GALLEZ B., LEMAIRE L. « Lipid nanocapsules for tissue oxygen determination using EPR and MRI ». In : 5th Annual meeting of the French Society for Nanomedicine (SFNano). 3-5/12/2018, Montpellier.

CHIAVACCI L., LEMAIRE L., BERBEL MANAIA E., FRANCONI F., LELIÈVRE B., BENOÎT J. – P. « Hydrophilic ZnO nanoparticles with luminescent and magnetic properties ». In : 5th Annual meeting of the French Society for Nanomedicine (SFNano). 3-5/12/2018, Montpellier.

LALLO DA SILVA B., LEMAIRE L., LEPELTIER E., BENOÎT J. – P., CHIAVACCI L. « Association of ZnO and GCIS/ZnS Quantum dots with optimized photoluminescence properties ». In : 5th Annual meeting of the French Society for Nanomedicine (SFNano). 3-5/12/2018, Montpellier.

R Jalleh, H Pham, C Marathe, T Wu, M Buttfield, S Hatzinikolas, C-H Malbert, R Rigda, K Lange, L Trahair, C Feinle-Bisset, C Rayner, M Horowitz, Karen Jones. Acute effects of lixisenatide on intragastric meal distribution in health and type 2 diabetes – impact on energy intake. Australasian diabetes congress, Sydney. Oral presentation

K Jones, L Huynh, S Hatzinikolas, R Rigda, L Phillips, H Pham, C Marathe, T Wu, C-H Malbert, K Lange, J Stevens, C Rayner, M Horowitz. Effects of exenatide once-weekly (QW) on gastric emptying, postprandial glycaemia and glucose absorption in health. Australasian diabetes congress, Sydney. Oral presentation

C Marathe, T.A. Murthy, J Grivell, S Hatzinikolas, C Rayner, L-A Chapple, M Chapman, J Stevens, C-H Malbert, M Horowitz, K Jones. ‘Gastric’ counter-regulation of hypoglycaemia in health – effects of ‘mild’ and ‘marked’ hypoglycaemia Australasian diabetes congress, Sydney. Oral presentation

X Wang, Z Sun, C-H Malbert, C S Marathe, K. L Jones, M. Horowitz, C. K Rayner, T. Wu. Ethnic disparities in gastric emptying and postprandial glycaemia in type 2 diabetes. BEXCO, Busan Korea. Oral presentation

K Jones, L Huynh, S Hatzinikolas, R Rigda, L Phillips, H Pham, C Marathe, T Wu, C-H Malbert, K Lange, J Stevens, C Rayner, M Horowitz. Effect of exenatide once-weekly (QW) on gastric emptying in health: impact on glycaemia and glucose absorption. EASD 2019 Barcelona. Plenary Oral presentation

L Huynh, S Hatzinikolas, R Rigda, L Phillips, H Pham, C Marathe, T Wu, C-H Malbert, K Lange, J Stevens, C Rayner, K Jones, M Horowitz. Effects of a guar/whey preload on gastric emptying and glycaemic responses to oral glucose in healthy older people ». EASD 2019 Barcelona. Poster

Malbert, A. Chauvin, F. Le Gouevec, J. Georges, M. Genissel. Lower binding potential of GLP-1 receptor in the pancreas as a consequence of diet- induced obesity. EANM 2019, Barcelona. Oral presentation

B DEDEY, D GRENIER, T LUCAS – 2019. Stress Concentration Analysis in A Heterogeneous Dough Gas Cell Wall at The Microscale: the effect of gluten/starch interaction and rheological moduli ratio.

RONDEAU MOURO, C. – 2019. Relations structure-fonction de l’amidon dans le pain et autres produits amylacés in : Newsletter N° 100 de la Veille Technologique en Biosciences de CBB Capbiotek. http://britta.cbb-developpement.com/veille/lettres/vtb/lettre_2019-4.html

EL HAJJ,C., MOUSSAOUI, S, COLLEWET, G., MUSSE,M. – 2019. Multi-Exponential Relaxation Times Maps Reconstruction and Unsupervised Classification in Magnitude Magnetic Resonance Imaging.

EL HAJJ,C., MOUSSAOUI S,, COLLEWET, G, MUSSE, M – 2019. Spatially Regularized Multi-Exponential Transverse Relaxation Times Estimation from Magnitude MagneticResonance Images Under Rician Noise.

EL HAJJ,C., MOUSSAOUI, S., COLLEWET, G., MUSSE, M. – 2019. Reconstruction et classification des temps de relaxation IRM multi-exponentielle.

MUSSE M. NMR and MRI Relaxometry Studies of Plant Tissues. Farewell Symposium for dr. Henk Van As “NMR/MRI, Plants and Foods: Does Size Matter?” 25/10/2019, Wageningen, NLD

RONDEAU-MOURO, C., LUCAS, T., GRENIER, D. – 2019. TD-NMR and MRI on bread – perspectives for Rheo-NMR. Workshop on Rheo-NMR, Karlsruhe, DEU, 11/01/2019

RONDEAU-MOURO, C. – 2019. Characterization of foodstuffs by NMR and MRI methods. Departamento de Tecnologia de Alimentos, Unicamp, Campinas, BRA, 25/02/2019

RONDEAU-MOURO, C., KOVRLIJA, R. , ROLLET, A.-L. , GRENIER, D., LUCAS, T. – 2019. Temperature and water associated changes of cereal products monitored by TD-NMR11th conference on Fast Field Cycling NMR Relaxometry, Pisa, ITA, 05/06/2019

MUSSE, M. – 2019. IRM quantitative pour la caractérisation des produits agroalimentaires . Journée scientifique sur la science des aliments et valorisation des bio-produits associant des chercheurs de l’IPR, l’ISCR, IRSTEA et l’INRA Rennes, FRA.

MUSSE, M., BILLIOT, B. – 2019. Nouvelles solutions d’imageries et biologiques pour comprendre et accroitre la résistance au stress hydrique et l’aptitude à la conservation des plants de pommes de terre. . Journée Agrophotonique – Végépolys.

TRAORE, AMIDOU , RONDEAU-MOURO, CORINNE , ALOUISSI, RIM , BENMOUSSA, ABDLATIF , BONNY, JEAN-MARIE, PAGES, GUILHEM – 2019. Profiling the temperature-dependent frequency of an open-magnet for outdoor applications. EURO-ISMAR 25-30/08/2019, Berlin, GR (poster)

LEFORESTIER R, MUSSE M, MARIETTE F. – 2019. Temperature dependence of T2 relaxation times in fresh tomato pericarp. 15th International Conference on Magnetic Resonance Microscopy (ICMRM), 18/08/19 – 22/08/19, Paris, France.

 

LEPORT, L., CAMBERT, M., LECONTE, P., BOUCHEREAU, A., MARIETTE, F., MUSSE, M. – 2018. NMR relaxometry monitoring for field phenotyping of nitrogen fertilization responses in Brassica napus. 21st Crucifer Genetics Conference – Brassica 2018  01/07/2018-04/07/2018, Saint Malo, FRA.

SORIN, C., MUSSE, M., MARIETTE, M. – 2018. NMR study of fresh cut escarole: influence of temperature and storage time on leaf structure and water repartition. 14th International Conference on the Applications of Magnetic Resonance in Food Science  17/09/2018-21/09/2018, Rennes, FRA.

EL HAJJ, COLLEWET, G., MUSSE, M., MOUSSAOUI, S. – 2018. Fruit tissues classification from MRI multi-exponential T2 maps. 14th International Conference on the Applications of Magnetic Resonance in Food Science  17/09/2018-21/09/2018, Rennes, FRA.

GRENIER, D., LUCAS, T., LE RAY, D – 2018. How does rheology affect the eye growth in semi-hard cheese? Gas pressure measurements in eyes and numerical simulations. 10th Cheese symposium, April 4-6, Rennes, FRA

GRENIER, D., DIASCORN, Y., RONDEAU-MOURO, C., GODFRIN, C., CAMBERT, M., ROUILLAC, J., LUCAS, T. – 2018. Bread baking under partial vacuum, Crumb softness of gluten-free bread during storage for 4 days. . AACC Cereals and Grains, October 21-23, London, UK.

Malbert C-H – Impact of long-term supplement with artificial sweeteners on insulin dependent glucose uptake. State of the art lecture, University of Adelaide, Adelaide.

Charles-Henri Malbert, R. Young, Francis Le Gouevec, Mickael Genissel, Alain Chauvin, et al.. Impact of long term supplement with artificial sweeteners on insulin dependent glucose uptake. European obesity meeting, Vienna, Austria

Charles-Henri Malbert, R. Young, Francis Le Gouevec, Mickael Genissel, Alain Chauvin, et al.. Altered brain processing after long-term artificial sweetener use, . European obesity meeting, Vienna, Austria

Charles-Henri Malbert, R. Young, Francis Le Gouevec, Mickael Genissel, Alain Chauvin, et al.. Impact of long term supplement with artificial sweeteners on insulin dependent glucose uptake. European Association of Nuclear Medicine, Dusseldorf, Germany

Charles-Henri Malbert, R. Young, Francis Le Gouevec, Mickael Genissel, Alain Chauvin, et al.. Altered brain processing after long-term artificial sweetener use, . European obesity meeting, Vienna, European Association of Nuclear Medicine, Dusseldorf, Germany

Charles-Henri Malbert, Quantification des processus physiopathologiques au moyen de l’imagerie préclinique multimodale, Rennes.

Le Ster, J. Lasbleiz, H. Saint-Jalmes, R. Guillin, G. Gambarota. Influence of the lipids on the quantification of IVIM parameters in the vertebral bone marrow. 26th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, Paris, France, 16-21 juin 2018.

Largent, L. Marage, I. Gicquiau, G. Gambarota, E. Chajon, O. Acosta, JC. Nunes, R. de Crevoisier, H. Saint-Jalmes,IRM en position de traitement pour la radiothérapie: Optimisation de sequences pour les cancer ORL. Journées Francophones de Radiologie, JFR 2018, Paris, 12-15 octobre 2018.

Saint-Jalmes, MRI hardware: bridging the gap between theory and images. 14th International Conference on the Applications of Magnetic Resonance in Food Science, September 17 to 21, Rennes, France

Nicolas, V. Bordeau, A. Bondon, M. Baudy Floc’h, B. Felden. New antibiotics active on multi-resistant bacteria. Challenges and new concepts in antibiotics research. Institut Pasteur, Paris, 19 – 21 mars 2018

CHIAVACCI L., LEMAIRE L., BERBEL MANAIA E., FRANCONI F., LELIÈVRE B. BENOÎT J.-P. « Hydrophilic ZnO nanoparticles with luminescent and magnetic properties ». In : 5th Annual meeting of the French Society for Nanomedicine (SFNano). 3-5/12/2018, Montpellier.

LALLO DA SILVA B., LEMAIRE L., LEPELTIER E., BENOÎT J.-P., CHIAVACCI L. « Association of ZnO and GCIS/ZnS Quantum dots with optimizedphotoluminescence properties ». In : 5th Annual meeting of the French Society for Nanomedicine (SFNano). 3-5/12/2018, Montpellier.

FRANCONI F. « Fat quantification with MRI ». In : 14th International Conference on the Applications of Magnetic Resonance in Food Science. 17-21/09/2018, Rennes.

ROLLAND J.-Y., LOZINSKI A., GIMEL J.-C., FRANCONI F., LEMAIRE L., CALVIGNAC B. « Fluid-poroelastic interface modelling for an implantable medical device: Application to brain tumours treatment ». In : 14ème journées d’étude des milieux poreux. 8-10/10/2018, Nantes.

ROLLAND J.-Y., LOZINSKI A., CALVIGNAC B., GIMEL J.-C., FRANCONI F., LEMAIRE L. « Fluid-poroelastic interface modelling for an implantable medical device: Application to brain tumours treatment ». In : 3rd Mathematical Biology Modelling days of Besançon. 19-22/06/2018, Besançon.

NEL J., FRANCONI F., JOUDIOU N., GALLEZ B., LEMAIRE L. « Lipid nanocapsules for tissue oxygenation determination using MRI ». In : Joint Annual Meeting ISMRM-ESMRMB . 16-21/06/2018, Paris.

CHIAVACCI L., LEMAIRE L., BERBER MANAIA E., FRANCONI F., LELIÈVRE B., BENOÎT J.- P. « Lipophilic and hydrophilic ZnO nanoparticles withluminescent and magnetic properties ». In : 11th world meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology. 19-22/03/2018, Grenade.

Poster

A.Bondon, A. El Harras, O. Delalande, I. Nicolas, V. Bordeau, B. Felden. New family of aza3 pseudopeptides active on multi-resistant bacteria. EUROMAR, Nantes, 1-5 juillet 2018.

El Harras, M. Simon, F. Desriac, M. Pugnière, P. Got, D. Destoumieux-Garzon, Y. Fleury, A.Bondon. Structure of a cyclolipopeptide in interaction with a lipopolysaccharide. EUROMAR, Nantes, 1-5 juillet 2018.

Giganti, G. Gambarota, C. Moore, N. McCartan, M. Emberton, C. Allen, A. Kirkham, The effects of dutasteride on quantitative T2 and T2-weighted imaging in men on active surveillance for prostate cancer: results from a placebo-controlled, randomized clinical trial. 26th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, Paris, France, 16-21 juin 2018.

Nemeth, B. Leporq, A. Coum, G. Gambarota, K. Seyssel, B. Segrestin, PJ Valette, M. Laville, O. Beuf, H. Ratiney, Effect of the phase variation induced by eddy currents on localized spectroscopy fatty acid composition quantification and its correction. 26th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, Paris, France, 16-21 juin 2018.

Bannier, G. Gambarota, JC Ferré, T. Kober, A. Nica S. Chabardes, C. Haegelen, FLAWS imaging improves depiction of the thalamic subregions for DBS planning in epileptic patients. 26th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, Paris, France, 16-21 juin 2018

Pavilla, A. Arrigo, G. Gambarota, M. Mejdoubi, R. Duvauferrier, H. Saint-Jalmes, Kurtosis and IVIM measurements applied to ischemic stroke diagnosis: an initial experience. 26th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, Paris, France, 16-21 juin 2018.

Dietrich, G. Dieuset, M. Lagarrigue, H. Saint-Jalmes, B. Martin, Ch. Pineau, F. Wendling, PA Eliat, Epileptogenesis Imaging biomarker identification in the Mesial Temporal lobe epilepsy (MTLE) mouse model. 26th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, Paris, France, 16-21 juin 2018.

SORIN, C., MARIETTE, F., MUSSE, M., LEPORT, L., CRUZ, F., YVIN, J.C. – 2018. Leaf development monitoring and early detection of water deficiency by low field NMR relaxation in Nicotiana tabacum leaves. 14th International Conference on the Applications of Magnetic Resonance in Food Science 17/09/2018-21/09/2018, Rennes, FRA.

EL HAJJ,C., COLLEWET, G., MUSSE, M., MOUSSAOUI,S. – 2018. Spatially regularized multi-exponential transverse relaxation times estimation from magnitude MRI images under Rician noise. Joint Annual Meeting ISMRM-ESMRMB 16/06/2018-21/06/2018, Paris, FRA.

MUSSE, M., CAMBERT, M., LECONTE, P., BOUCHEREAU, A., MARIETTE, M., LEPORT, L. – 2018. 1. NMR approach to evaluate impact of nitrogen supply on the senescence process of Brassica napus leaves under field conditions. 14th International Conference on the Applications of Magnetic Resonance in Food Science 17/09/2018-21/09/2018, Rennes, FRA.

MUSSE, M., BIDAULT, K., QUELLEC, S., GENARD, M., VERCAMBRE, G., BRUNEL, B., CAMBERT, M., BERTIN, N. – 2018. Quantitative magnetic resonance imaging of peach fruit during development. 14th International Conference on the Applications of Magnetic Resonance in Food Science 17/09/2018-21/09/2018, Rennes, FRA.

EL HAJJ, C., COLLEWET, G., MUSSE, M., MOUSSAOUI, S. – 2018. Spatially regularized multi-exponential transverse relaxation times estimation from magnitude MRI images under Rician noise. International Society for Magnetic Resonance in Medicine 16/06/2018-21/06/2018, Paris, FRA.

RONDEAU-MOURO, C., CAMBERT, M., GODFRIN, C., ROUILLAC, J., DIASCORN, Y., LUCAS, T., GRENIER, D. – 2018. TD-NMR characterization of crumb in gluten-free bread baked under partial vacuum. AACC Cereals and Grains, October 21-23, London, UK.

RONDEAU-MOURO, C., KOVRLIJA, R. – 2018. Quantification of water sorption in starch-glycerol extrudates by MR micro-imaging.. MRFOOD 2018 September 17 to 21, Rennes, FR

GODFRIN, C., CAMBERT, M., ROUILLAC, J., DIASCORN, Y., LUCAS, T., GRENIER, D., RONDEAU MOURO, C. (2018). Gluten-free bread baked under reduced pressure characterized by TD-NMR. MRFOOD 2018 September 17 to 21, Rennes, FR.

Mosbah, W. Ayadi, E. Sahli, S. Chevance, A. Bondon, A. Gargouri, M. Baudy-Floc’h , R. Mokdad-Gargouri, B1.12: a novel peptide interacting with the extracellular loop of the EBV oncoprotein LMP1.N. Ammous-Boukhris, Sci. Reports, 2019, 9, 4389.

Richard, E. Petit, L. Pouységu, J-P. Monti, A. Bondon, T. Sylla, J-M. Mérillon, S. Quideau, G. Da Costa, Impact of polyphenols on receptor–ligand interactions by NMR: the case of neurotensin (NT)–neurotensin receptor fragment (NTS1) complex. J. Biomol. Struct. Dyn., 2019, 1-12.

H-D. Vu, C. Bouvry, J. Renault, A. Bondon, F. Lambert, T. Roisnel, P. Uriac,Reactivity of 5-alkynyl-3,4-dihydro-2H-pyrroles with Au(III): Route to vinylgold(III) complexes, aurocycles by cyclisation of these complexes and ML complexes. Organomet. Chem., 2019, 897, 228-235.

Nicolas, V. Bordeau, A. Bondon, M. Baudy-Floc’h, B. Felden,Novel antibiotics effective against Gram-positive and negative multi-resistant bacteria with limited resistance. PLOS Biol, 2019, 17(7): e3000337.

Legouin, A. Bondon, C. Orione, S. Ferron, P. Uriac, Study of the self-association of molecular tweezers bearing two different arms: influence of the stereoelectronic effects of the arm substituents. Journal J. Incl. Phenom. Macrocycl. Chem., 2019. DOI: 10.1007/s10847-019-00954-2

Gaucher F., Bonnassie S., Rabaha H, Leverriere P, Pottier S., Jardina J., Briard-Biona V., Marchand P., Jeantet R., Blanc P., Jan G. Benefits and drawbacks of osmotic adjustment in Propionibacterium Freudenreichii, Journal of Proteomics 2019, 204, 103400. https://doi.org/10.1016/j.jprot.2019.1034007)

Gaucher F., Kponouglo K., Rabah H., Bonnassie S., Ossemond J., Pottier S., Jardin J., Briard-Bion V., Marchand P., Blanc P., Jeantet R. and Jan G., Propionibacterium freudenreichii CIRM-BIA 129 osmoadaptation coupled to acid-adaptation increases its viability during freeze-drying. Front. Microbiol. 2019, 10:2324. doi: 10.3389/fmicb.2019.02324

Bonnassie S., Pottier S., Marchand P., Jan G., Blanc P., Jeantet R., Taking advantage of bacterial adaptation in order to optimize industrial production of dry Propionibacterium freudenreichii. Gaucher F., Gagnaire V., Rabah H., Maillard M.-B., Microorganisms 2019, 7(10), 477. doi:10.3390/microorganisms7100477

Mocanu A, Szűcs R, Caytan E, Roisnel T, Dorcet V, Bouit P-A, et al.. Synthesis, Optical, and Redox Properties of Regioisomeric Benzoheterocycles-Fused Pyrene. J.Org.Chem. 2019, 84, 957−962. DOI:10.1021/acs.joc.8b02884

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